This is the process that allows cells to form double-membraned vesicles so they can sequester proteins and organelles and mark them for degradation in the lysosome. Evidence suggests that there may be a role for autophagy in a tumor microenvironment. Specifically, autophagy in the presence of cancer is thought to help cancer cells cope with a hypoxic environment, nutrient shortages, and combating some therapies.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.