Tumor angiogenesis is the proliferation of blood vessels that supply tumors with a supportive microenvironment rich in nutrients and oxygen that are required for growth, maintenance, and metastasis. It is mediated by of tumor vascular endothelial growth factor A (VEGF-A), which is expressed in most types of cancer.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.