The AMP-activated protein kinase (AMPK) pathway is a central regulator of cellular metabolism, which is activated when intracellular adenosine triphosphate (ATP) levels are low. It is known to play a critical role in reprogramming cellular metabolism, regulating growth, cell polarity, and autophagy activity.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.