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Signaling Pathways

ErbB/HER Signaling

The ErbB receptor tyrosine kinase family has four cell surface receptors: ErbB1/EGFR/HER1, ErbB2/HER2, ErbB3/HER3, and ErbB4/HER4. ErbB receptors signal through Akt, MAPK, and many other pathways to regulate cell proliferation, motility, migration, cell differentiation, and apoptosis. Given that ErbB receptors can be over-expressed, amplified, or mutated in various types of cancer, researchers are interested in them as therapeutic targets.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.

Adherens Junction Alzheimer's disease AMPK pathway Angiogenesis Apoptosis Inhibition Apoptosis(Overview) ATP Related Chromatin Remodel Autophagy B Cell Receptor signaling Cell Cycle G1/S Cell Cycle G2/M Cell Intrinsic Innate Immunity Cell Extracellular Matrix and EMT Cell Soluble Factors and EMT Crosstalk PostTrans Death Receptor DNA Methylation Dopamine Parkinsons Epigenetic Histone H2A/H2B/H4 Epigenetic Histone H3 ErbB/HER Signaling ES pluripotency and Differentiation Glutamine metabolism Hedgehog Hippo Signaling Histone Methylation Hypoxia Immune Cell Markers(Human) Immune Cell Markers(Mouse) Immune Checkpoint in TME Inflammasome Insulin Receptor Jak/Stat:IL6 Signaling MAPK/ERK in Growth and Differentiation MAPK/ERK and G_Protein MAPK_p38 mTOR Necroptosis NF-κB Signaling Notch Signaling Nuclear Receptor Phosphoinositide lipid signaling Phospholipase Protein Acetylation Protein Kinase C Signaling Pyroptosis Regulation of Actin SAPK/JNK Signaling T Cell Receptor TGF-β Signaling Toll Like Receptor Signaling Translation：eIF2 Translation：eIF4 Translation（Overview） Tumor Angiogenesis Ubiquitin Proteasome Vesicle Trafficking Warburg Effect Wnt ß-catenin Signaling Akt/PI3 Kinase