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Signaling Pathways

Hypoxia

This pathway is activated when the body or cells have limited oxygen. The pathway is mediated by hypoxia-inducible factor (HIF). Under hypoxic conditions, HIF is stabilized and translocated into the nucleus. Once in the nucleus HIF binds to HIF1B, which increases the transcription of HIF target genes.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.

Adherens Junction Alzheimer's disease AMPK pathway Angiogenesis Apoptosis Inhibition Apoptosis(Overview) ATP Related Chromatin Remodel Autophagy B Cell Receptor signaling Cell Cycle G1/S Cell Cycle G2/M Cell Intrinsic Innate Immunity Cell Extracellular Matrix and EMT Cell Soluble Factors and EMT Crosstalk PostTrans Death Receptor DNA Methylation Dopamine Parkinsons Epigenetic Histone H2A/H2B/H4 Epigenetic Histone H3 ErbB/HER Signaling ES pluripotency and Differentiation Glutamine metabolism Hedgehog Hippo Signaling Histone Methylation Hypoxia Immune Cell Markers(Human) Immune Cell Markers(Mouse) Immune Checkpoint in TME Inflammasome Insulin Receptor Jak/Stat:IL6 Signaling MAPK/ERK in Growth and Differentiation MAPK/ERK and G_Protein MAPK_p38 mTOR Necroptosis NF-κB Signaling Notch Signaling Nuclear Receptor Phosphoinositide lipid signaling Phospholipase Protein Acetylation Protein Kinase C Signaling Pyroptosis Regulation of Actin SAPK/JNK Signaling T Cell Receptor TGF-β Signaling Toll Like Receptor Signaling Translation：eIF2 Translation：eIF4 Translation（Overview） Tumor Angiogenesis Ubiquitin Proteasome Vesicle Trafficking Warburg Effect Wnt ß-catenin Signaling Akt/PI3 Kinase