The phosphatidylinositol-3-kinase (PI3K)/AKT pathway is involved in cell cycle regulation. It is interconnected with the mammalian target of rapamycin (mTOR) signaling pathway. Together they play a critical role in cell growth, cell survival especially during cellular stress (e.g., a tumor environment).

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.