Under healthy conditions, the mammalian target of rapamycin (mTOR) participates in multiple signaling pathways and is known to regulate various cellular processes including cell proliferation, autophagy, and apoptosis. In a tumor microenvironment the mTOR signaling pathway regulates gene transcription, protein synthesis, and immune cell differentiation but it also plays an important role in tumor metabolism.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.