Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by synaptic loss, accumulation of amyloid B plaques and neurofibrillary tangles (NFTs). The AD pathways consist of the amyloid B cleavage and degradation pathways, APOE-cholesterol pathway, and the NFT accumulation pathway. Although a large part of the biological components of AD are not characterized, there is a strong genetic correlation AD and these three genes: amyloid precursor protein (APP), presenilin 1 (PSSEN1), and presenilin 2 (PSEN2).

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.