Glutamine is the most abundant amino acid in the human body and is used in the biosynthesis of proteins. Glutamine is considered fuel for immune cells and plays a crucial role in healthy immune cell function. Glutamine metabolism involves several enzymes including glutamine synthetase (GS) and phosphate-dependent glutaminase (GLS). GS is involved in the reaction that makes glutamine from ammonium ion. It is also involved in the synthesis of glutamate via ATP consumption, while GLS is responsible for glutamine hydrolysis.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.