Phosphoinositides (PPIns) are lipid signaling molecules that coordinate membrane trafficking and cell signaling. They play an essential role in cell growth, metabolism, and cell death. The phosphoinositide 3-kinase (PI3K) signaling pathway is a critical signal transduction process that links the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes to multiple cellular functions.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.