KNOCKOUT & CONDITIONAL KNOCKOUT MOUSE MODELS
Knockout & Conditional Knockout Mouse Models
GemPharmatech makes it easy to find the knockout (KO) or conditional knockout (cKO) strain that fits your research. Our Pathways Page provides more than 60 interactive pathway diagrams covering cellular processes, structures, and proteins. By clicking on an active component within a pathway, you can instantly see the available KOAP strains connected to that gene or function. This makes it simple to identify models that are directly relevant to your research focus.
Use our interactive pathway browser to quickly locate the knockout models most relevant to your work
Save up to 50% on KO and cKO MICE!
For a limited time only, advance your research with exclusive savings on our knockout and conditional knockout mouse models. Take advantage of this offer to accelerate your next project at reduced cost!
Advantages of Our Knockout All Project:
Largest collection of gene editing mouse strains
Over 22,000+ available knockout and conditional knockout mouse model strains with more in development
Customized construction of knockout mice and conditional knockout mice
If a KO or cKO mouse strain is not yet available, one can be created in as little as 3-6 months
Access to our comprehensive services platform, including phenotyping, drug efficacy testing, in vitro pathological analysis, and more
Quick, hassle-free customer service
Orders can be placed online or with our expert sales representatives
Applications of Knockout Models
KO and cKO models are used across a wide range of biomedical research areas, such as:
Oncology – tumor initiation, progression, immunotherapy
Autoimmunity & Immunology – immune pathways and disease mechanisms
Neurodegeneration – Alzheimer’s, Parkinson’s, ALS
Cardiovascular Research – atherosclerosis, hypertension, cardiac genetics
Drug Discovery – target validation, safety, and preclinical efficacy
How It Works
Search Our Strain Database or Request a Custom Design
Browse our catalog of knockout and conditional knockout strains to see if the model you need is already available. With over 11,500 genes targeted, many commonly studied models can be provided immediately. If your gene of interest isn’t listed, our team can design a custom strategy using CRISPR/Cas9 or other editing methods.
Submit an Inquiry
Use the detailed inquiry form to share project requirements, including strain number, genetic background, desired format (live, cryopreserved embryos, or sperm), and any special considerations. Our scientific team will review your request and confirm feasibility, timelines, and options for customization.
Model Generation & Quality Control
For custom mouse model projects, our gene editing experts generate your KO or cKO strain in approximately 3–6 months. Each strain undergoes rigorous quality control, including genotyping and validation, to ensure accuracy and reproducibility.
Delivery in the Format You Need
Models are delivered in the format that best suits your research:
Live mice for immediate experimental use
Cryopreserved embryos for flexible storage and recovery
Sperm samples for cost-efficient preservation or breeding programs
Ongoing Support & Integrated Services
Our partnership doesn’t end with delivery. Researchers gain access to a full platform of services, including:
Phenotyping to assess gene function and validate models
Drug efficacy and safety testing
In vitro and pathology analysis
Breeding, colony management, and germ-free options
Frequently Asked Questions
Q: What’s the difference between a knockout and a conditional knockout mouse?
A knockout (KO) mouse is engineered so that a specific gene is permanently inactivated (“knocked out”) in every cell of the body. This makes it possible to study what happens when that gene is completely absent—for example, identifying its role in disease development or normal physiology.
A conditional knockout (cKO) mouse provides more flexibility: the gene can be deactivated only in certain tissues (e.g., brain, liver, immune cells) or at specific times in development. This avoids potential embryonic lethality or systemic side effects and allows researchers to isolate the role of a gene in one organ system or stage of life.
Q: How quickly can I get a custom KO or cKO model?
Standard turnaround is 3 to 6 months. The exact timeline depends on factors like gene size, strategy design, and whether preliminary resources (such as embryonic stem cells or CRISPR-ready constructs) already exist. For some high-priority genes, existing cryopreserved strains can be recovered faster. Projects involving complex edits (like multiple floxed sites or tissue-specific promoters) may take longer, but our team provides detailed project timelines up front.
Q: How do I order a knockout or conditional knockout mouse?
You can begin by searching our strain catalog or contacting us directly with your gene of interest. Use the inquiry form at the bottom of this page to provide details such as strain number, background, and desired format (live, cryopreserved, or sperm). Our scientific and sales teams will confirm availability, delivery timelines, and any additional options for customization. For genes not yet available, we’ll walk you through the custom model generation process.
Q: Do you provide supporting services beyond model generation?
Yes. GemPharmatech offers a full service platform designed to support researchers from early discovery through preclinical testing. This includes:
Phenotyping to characterize the effects of gene knockouts
Drug efficacy testing in KO and cKO models
In vitro assays and pathology analysis
Custom breeding and colony management
Microbiome and germ-free services when needed
This integration reduces the need to coordinate multiple vendors and keeps your research moving efficiently.
Q: What research areas are knockout and conditional knockout mice used in?
KO and cKO models are widely used across many fields of biomedical research.
Examples include:
Oncology: tumor suppressor gene knockouts to model cancer initiation and drug resistance
Immunology & Autoimmunity: cKO models that reveal immune cell-specific gene functions
Metabolic Disease: studying genes linked to obesity, diabetes, and lipid metabolism
Neuroscience: KO models that mimic Alzheimer’s, Parkinson’s, or ALS
Cardiovascular Research: models of atherosclerosis, hypertension, and cardiomyopathy
Drug Discovery & Target Validation: confirming whether disabling a gene is therapeutic before advancing to clinical trials
Q: What formats are available for delivery?
A: Most strains are available as live mice, cryopreserved embryos, or sperm. Cryopreserved options allow for cost-efficient storage and later recovery. For active projects, live deliveries in specific ages or sexes can be arranged. Our team will confirm the options available for your chosen strain during the ordering process.
Get more in-depth insights into our KOAP project!
Learn how GemPharmatech’s ambitious KOAP initiative is transforming biomedical research! In this webinar, our experts explain how knockout and conditional knockout models are generated, the scale of our strain library, and common research applications. Topics include disease model development, use cases in oncology and metabolism, and much more.
In this on-demand webinar, we explore:
An introduction into the KOAP project and its goals
An overview of the gene-editing technology powering our KO/cKO models
Key research fields thatcan benefit from the initiative
Advantages of access to the world’s largest repository of knockout and conditional knockout mice
Accelerate your research with GemPharmatech’s KO and cKO mouse models! Our expert team is ready to help you choose the right model or build a custom solution.