Nuclear receptors (NRs) are transcription factors that regulate several biological processes (e.g., cell growth, development, metabolism, and inflammation). Binding of NRs ligands triggers a cascade of events that can lead to various transcriptional responses including ligand-induced NR conformational changes and engagement of DNA sequences and coregulatory proteins. NRs are associated with many pathologies including cancer, inflammation, and cardiovascular disease.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.