Pyroptosis is a form of cell death that is triggered by proinflammatory signals. In pyroptosis the cell nucleus remains intact and gasdermin pores form on the plasma membrane, which results in an influx of water and eventual cell lysis. Pyroptosis is receiving a lot of attention because of its involvement with innate immunity and its ability to affect the development of tumors.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.