Toll-like receptors (TLRs) play an essential role in the innate immune system and antigen-specific acquired immunity. They recognize specific molecular patterns that are present on microbes. TLRs also activate the transcription factors NF-κB and IRFs, which can result in the activation of innate immune responses.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.