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STZ induced TID models


Streptozotocin (STZ) is a widely used chemical agent used to induce type 1 diabetes in rodent models, including NCG and C57BL/6J (B6) mice. STZ selectively destroys pancreatic beta cells via necrosis, leading to insulin deficiency and hyperglycemia. This model is valuable for studying the pathophysiology of type 1 diabetes and testing potential therapeutic interventions.

 

Study outline


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1. STZ-Induced Type I Diabetes in NCG Mice


1.1 NCG mice show increased blood glucose level and decreased plasma insulin after STZ exposure.

 

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Data presented as mean±SEM,**,****denoted p<0.01, p<0.0001 vs NCG+Vehicle, respectively.

 

1.2 STZ induced aggravation of islet damage: the number of islets decreased, the shape was irregular, and islets boundary was unclear with duct enlarged.

 

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2. STZ-Induced Type I Diabetes in C57BL/6J Mice


2.1 B6 mice show increased blood glucose level after STZ exposure.


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