Disease Rat Models
Rats have long been a cornerstone of biomedical research, offering unique advantages that make them important for translational studies. With their larger size compared to mice, rats allow for easier surgical manipulations, more precise pharmacokinetic sampling, and more sophisticated behavioral assessments. Their physiology and metabolism often more closely mirror human systems, providing predictive value for therapeutic development. At GemPharmatech, we have a growing portfolio of different rat models, designed to accelerate your research from target validation to preclinical efficacy.
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60% HFD Induced DIO Rat Models
Obesity is a chronic metabolic disorder characterized by excessive fat accumulation that poses significant risks to health. It arises from a complex interplay of genetic, environmental, behavioral, and hormonal factors, primarily driven by prolonged energy imbalance (caloric intake exceeding expenditure).
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Adenine-induced Rat CKD Model
Chronic kidney failure, also known as chronic kidney disease (CKD), is a progressive and irreversible deterioration of kidney function over months or years. It results in the kidneys' inability to effectively filter waste, regulate electrolytes, maintain fluid balance, and produce essential hormones.
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5/6 Nephrectomy-induced Rat CKD Model
Chronic kidney failure, also known as chronic kidney disease (CKD), is a progressive and irreversible deterioration of kidney function over months or years. It results in the kidneys' inability to effectively filter waste, regulate electrolytes, maintain fluid balance, and produce essential hormones. At GemPharmatech, we offer validated models of CKD to meet your research needs.
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CCL4-induced Chronic Liver Fibrosis Models in SD Rat
Liver fibrosis is a pathological wound-healing response to chronic liver injury characterized by excessive accumulation of extracellular matrix (ECM) proteins that disrupt normal liver structure. Common causes include viral hepatitis, alcohol abuse, metabolic dysfunction, and toxic impairment. If left untreated, fibrosis may progress to cirrhosis, portal hypertension, and liver failure.
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CDAHFD-induced Rat MASH Model
Metabolic Dysfunction-Associated Steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH), is the progressive inflammatory stage of metabolic dysfunction-associated steatotic liver disease (MASLD). It is characterized by hepatic steatosis (≥5% fat accumulation), inflammation, hepatocyte injury (ballooning), and fibrosis, which can progress to cirrhosis and hepatocellular carcinoma (HCC).
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45％HFHS+STZ induced Type I Diabetes Models in SD Rat
Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. GemPharmatech provides a validated model of type I diabetes in SD rats to meet your research needs.
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OVX-induced Rat Osteoporosis Model
Osteoporosis is a systemic skeletal disorder characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to increased bone fragility and higher fracture risk.
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MCAO-induced CIS Model in SD Rat
Ischemic cerebral infarction refers to hemiplegia and disturbance of consciousness caused by cerebral infarction or cerebral artery blockage on the basis of cerebral thrombosis.
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2K1C-induced Hypertension Model in SD Rat
Hypertension (HTN) is a chronic medical condition characterized by persistently elevated systemic arterial blood pressure (BP).