Autoimmune Disease Efficacy Evaluation
Autoimmune diseases arise from dysregulation of the immune system, in which the body's immune system mistakenly attacks its own healthy tissues. This leads to tissue damage and chronic inflammation across multiple organ systems. With the global burden of autoimmune conditions such as lupus, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis steadily rising, there is a critical need for robust translational preclinical models. GemPharmatech offers one of the most comprehensive portfolios of autoimmune disease models, including genetically engineered mice, humanized strains, and induced disease models. Our models enable researchers to dissect disease mechanisms, evaluate therapeutic efficacy, and accelerate drug development across a wide range of autoimmune and inflammatory indications. Combined with our integrated preclinical services, GemPharmatech provides a one-stop solution to help you advance novel immunotherapies from discovery to clinical translation.
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Autoimmune Nephropathy Models and Efficacy Services
Autoimmune nephropathy occurs when the immune system mistakenly attacks renal tissues. Subtypes of Immune - Related Nephropathy (IRN) include conditions such as immunoglobulin A nephropathy (IgAN), C3 glomerulopathy, lupus nephritis, among others. Immune complexes or autoantibodies generated during such autoimmune responses can damage glomeruli, tubules, or blood vessels, leading to proteinuria, hematuria, and reduced kidney function. Inflammation and fibrosis often follow, potentially progressing to end - stage renal disease. Diagnosis relies on urine tests, blood work, and kidney biopsies and treatments aim to suppress autoimmunity with immunosuppressants or corticosteroids to manage symptoms and preserve renal function.
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Asthma Models and Efficacy Services
Asthma is a chronic inflammatory disorder of the respiratory system that can affect individuals of all ages. Characterized by airway inflammation and smooth muscle constriction, asthma leads to breathing difficulties due to the narrowing of bronchial passages. Common symptoms include persistent dry cough (especially at night), dyspnea, chest tightness or pain, and the audible wheezing sound resulting from restricted airflow.
To help with your preclinical studies, we have developed and validated several induced models of asthma in mice. They include an ovalbumin (OVA) induced asthma model as well as a house dust mite (HDM) induced asthma model. -
Systemic Lupus Erythematosus (SLE) Models and Efficacy Services
Systemic Lupus Erythematosus (SLE) is a classic autoimmune disease characterized by the presence of numerous autoantibodies in the patient's blood and multi-organ involvement. Current research indicates that genetic, endocrine, infectious, immune abnormalities, and certain environmental factors may all contribute to the development of SLE. Therefore, the pathogenesis of SLE and innovative drugs/therapies urgently need to be elucidated. In the quest to unravel the pathogenesis of SLE and identify effective therapeutic agents, SLE animal models have played a pivotal role. These models not only provide a preclinical platform to investigate the mechanisms underlying SLE development but also serve as disease surrogates for the development and evaluation of novel therapeutics. In recent years, researchers worldwide have established diverse SLE animal models, which can be broadly categorized into genetically driven spontaneous models and environmentally induced models.
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Sjögren's Syndrome Models and Efficacy Services
Sjögren's syndrome (SS) is an autoimmune disorder that primarily affects the exocrine glands. It particularly targets the salivary and lacrimal glands, resulting in dry mouth (xerostomia) and dry eyes (xerophthalmia). Sjögren's syndrome can also involve other organs and systems, causing various symptoms such as joint pain, fatigue, and difficulties in swallowing.
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Neuroimmune Diseases Models and Efficacy Services
Neuroimmune diseases are disorders arising from abnormal interactions between the nervous and immune systems. These diseases can cause neurological symptoms such as paralysis, sensory loss, and cognitive impairment. Mechanisms often involve autoimmunity, neuroinflammation, and disrupted blood - brain barrier function. Current research focuses aim to understand immune cell infiltration into the nervous system and the effects of cytokine - mediated damage, with the goal of developing immunomodulatory therapies to improve patient outcomes.
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Autoimmune Dermatoses Models and Efficacy Services
Autoimmune dermatoses are skin disorders where the immune system mistakenly attacks healthy skin cells, leading to inflammation and tissue damage. Common examples include psoriasis, atopic dermatitis and vitiligo. These conditions often involve cytokines, autoantibodies, and immune cell infiltration. Diagnosis relies on clinical examination, histopathology, and serological tests, while treatment strategy is aimed at suppressing abnormal immune responses with topical or systemic immunosuppressants, phototherapy, or biologics, targeting pathways like TNF-α, IL-17 or Th2 cytokines to alleviate symptoms and improve quality of life.
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Inflammatory Bowel Disease (IBD) Models and Efficacy Services
Inflammatory Bowel Disease (IBD) is a group of chronic gastrointestinal disorders characterized by persistent intestinal inflammation. The main types of IBD are Crohn’s disease (affecting any part of the digestive tract) and ulcerative colitis (limited to the colon and rectum). Symptoms include abdominal pain, diarrhea, weight loss, and rectal bleeding. IBD arises from a dysregulated immune response to gut microbiota, genetic predisposition, and environmental factors. Chronic inflammation leads to mucosal damage, epithelial barrier dysfunction, and systemic complications like arthritis or skin lesions. Diagnosis involves endoscopy, imaging, and biopsies while treatment strategies center around reducing inflammation with immunosuppressants, biologics (e.g., anti-TNF agents), and lifestyle adjustments.
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Rheumatoid Arthritis (RA) Models and Efficacy Services
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects millions of individuals worldwide. This debilitating condition primarily targets the joints, causing pain, swelling, morning stiffness, and irreversible damage if left uncontrolled.
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Immune Reconstitution Autoimmune Disease Models and Efficacy Services
Immune reconstitution autoimmune disease models are generated based on human immune system-reconstituted mice. Immunodeficient mice are infused with human PBMC (peripheral blood mononuclear cells) or HSC (hematopoietic stem cells) to reconstitute human immune cells, including T cells, B cells, NK cells, myeloid cells, and other immune populations. Specific agents are administered to the mice to induce autoimmune disease phenotypes making these models ideal for drug evaluation purposes.