Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive form of non-alcoholic fatty liver disease which develops when excessive fat accumulates in the liver, triggering inflammation and subsequent damage to liver cells. Strongly linked to metabolic abnormalities like obesity, insulin resistance, and type 2 diabetes, MASH can advance to severe liver pathologies, including liver fibrosis, cirrhosis, and liver cancer. Distinct from simple fatty liver, MASH is characterized by active liver injury. Accurate diagnosis typically necessitates a comprehensive approach, integrating blood tests, imaging modalities, or liver biopsies.