Diabetes is a group of metabolic diseases caused by genetic, environmental, or immunologic factors that lead to hypoglycemia and insulin resistance, which in turn leads to more complicated metabolic dysfunctions. Diabetes is subdivided into type I diabetes, type II diabetes, and other unique forms, with type II diabetes accounting for around 90% of people with diabetes. GemPharmatech has developed a series of diabetes models for pathogenesis study and drug evaluation through gene editing and diet treatment.
An 11-bp base deletion in exon 8 of the Alms1 gene in C57BL/6JGpt mice led to early termination of translation of the Alms1 gene, leading to a combined phenotype of obesity, early diabetes and non-alcoholic fatty liver disease. These mice are ideal models for studies on obesity and fatty liver.
C57BLKS/JGpt mice lacking the Lepr gene develop severe morbid obesity, significant and persistent increase in blood glucose, islet damage and atrophy, severe insulin resistance, severe diabetic nephropathy, and diabetic retinopathy. These mice are ideal models for studying Type II diabetes and related complications.