Diabetes Models

Wild Mouse 750
Wild Mouse 750
Human Xenograft Models
Cell Derived Xenograft Models
Autoimmune Disease Models
Systemic Lupus Erythematosus ModelsMultiple Sclerosis ModelsRheumatoid Arthritis ModelsPsoriasis ModelsInflammatory Bowel Disease ModelsAtopic Dermatitis Models Asthma Models
Metabolic Disease Mouse Models
Obesity ModelsDiabetes ModelsNon-alcoholic Steatohepatitis (NASH) ModelsHyperlipidemia ModelsOsteoporosis ModelsHyperuricemia Models
Humanized Immune System Models
huPBMC-NCGhuHSC-NCG-XhuHSC-NCG-hIL15huHSC-NCG
Organs or Tissue Humanized Mouse Models
Wild Mouse 765
Wild Mouse 765
Rare Disease Mouse Models
Progressive Muscular Dystrophy ModelsHemophilia A Models
Neurodegenerative Disease Mouse Models
Alzheimer’s Disease (AD) ModelsParkinson’s Disease (PD) ModelsHuntington's Disease (HD) ModelsAmyotrophic Lateral Sclerosis (ALS) ModelsTransthyretin Amyloidosis (ATTR) Models
Immuno-Oncology Mouse Models
Human Xenograft ModelsHumanized Immune Checkpoint ModelsHumanized Immune System ModelsSpontaneous Tumor Models

Diabetes is a group of metabolic diseases caused by genetic, environmental, or immunologic factors that lead to hypoglycemia and insulin resistance, which in turn leads to more complicated metabolic dysfunctions. Diabetes is subdivided into type I diabetes, type II diabetes, and other unique forms, with type II diabetes accounting for around 90% of people with diabetes. GemPharmatech has developed a series of diabetes models for pathogenesis study and drug evaluation through gene editing and diet treatment.

 

Strain No.

Strain Name

Description

T017633

B6-Alms1-del(c.3802-3812)

An 11-bp base deletion in exon 8 of the Alms1 gene in C57BL/6JGpt mice led to early termination of translation of the Alms1 gene, leading to a combined phenotype of obesity, early diabetes and non-alcoholic fatty liver disease. These mice are ideal models for studies on obesity and fatty liver.

T002407

BKS-db

C57BLKS/JGpt mice lacking the Lepr gene develop severe morbid obesity, significant and persistent increase in blood glucose, islet damage and atrophy, severe insulin resistance, severe diabetic nephropathy, and diabetic retinopathy. These mice are ideal models for studying Type II diabetes and related complications.