Progressive Familial Intrahepatic Cholestasis Models

Some autosomal recessive mutations in the bile acid membrane transporters affecting hepatocytes lead to progressive familial intrahepatic cholestasis (PFIC), a group of diseases characterized by cholestasis, pruritus, and often an eventual requirement for liver transplantation. The estimated incidence of PFIC ranges from 1 in 50,000 to 1 in 100,000 live births.


● Genetically Engineered PFIC Mouse Models

Strain No.
Strain Name Strain Type Description
T012640 Nr1h4-KO Knockout Nr1h4-KO homozygous mice show impaired liver function and elevated serum TBA level. Lipid metabolism in this model is also impaired, as indicated by reduced serum TG and increased serum cholesterol levels
T007421 Abcb4-KO Knockout Abcb4-KO homozygous mice show impaired liver function and development of liver fibrosis from 8 weeks old