Autoimmune Nephropathy models

Wild Mouse 750
Wild Mouse 750
Human Xenograft Models
Cell Derived Xenograft Models
Autoimmune Disease Models
Autoimmune Nephropathy modelsAcute Lung Injury ModelsIdiopathic Pulmonary Fibrosis ModelsSjögren’ s Syndrome ModelsSystemic Lupus Erythematosus (SLE) ModelsMultiple Sclerosis ModelsRheumatoid Arthritis ModelsPsoriasis ModelsInflammatory Bowel Disease ModelsAtopic Dermatitis Models Asthma Models
Metabolic Disease Mouse Models
Obesity ModelsDiabetes ModelsMASH ModelsHyperlipidemia ModelsOsteoporosis ModelsHyperuricemia Models
Humanized Immune System Models
huPBMC-NCGhuHSC-NCG-XhuHSC-NCG-hIL15huHSC-NCG
Organs or Tissue Humanized Mouse Models
Wild Mouse 765
Wild Mouse 765
Rare Disease Mouse Models
Progressive Muscular Dystrophy ModelsHemophilia A Models
Neurodegenerative Disease Mouse Models
Alzheimer’s Disease (AD) ModelsParkinson’s Disease (PD) ModelsHuntington's Disease (HD) ModelsAmyotrophic Lateral Sclerosis (ALS) ModelsTransthyretin Amyloidosis (ATTR) Models
Immuno-Oncology Mouse Models
Human Xenograft ModelsHumanized Immune Checkpoint ModelsHumanized Immune System ModelsSpontaneous Tumor Models

Autoimmune nephropathy refers to a group of kidney diseases caused by the body's immune system mistakenly attacking the kidneys. These conditions can lead to inflammation and damage to the structures of the kidneys, impairing their function. 


图片4.png


1. B6-hBAFF_lupus nephritis mouse model (Strain No. T036794)

• Humanized BAFF mouse model is established through transgenic expression of human BAFF in B6 mice.

• This model could be used for study the mechanism of BAFF involved disease and evaluation the drug targeting for BAFF.


2. BSA+CCl4+LPS induced IgA nephropathy mouse model 


图片5.png

图片6.png

图片7.png

图片8.png

IgA staining( 4 weeks after LNP023/Astrasentan treatment, LNP023-complement factor B inhibitor, Astrasentan-endothelin A receptor antagonist )


3. B6-hC3_ C3 glomerulopathy mouse model (Strain No. T056196) 

图片9.png

Urine were collected from male B6 and B6-hC3 mice for analysis(4-6 weeks). Urine biochemical analysis revealed the B6-hC3 mice presented with significant elevation of UACR, markers of glomerular filtration, indicating glomerular injury.


4. Membranous Nephropathy (MN) mouse model


图片10.png

图片11.png