Human Xenograft Models
Xenograft is a tissue graft or organ transplant from a donor of a different species from the recipient. When using mouse models for the study of human diseases, the most common type of xenograft is the transfer of human tissue, including cells, biopsies or the entire organ to a mouse recipient. To study GvHD (graph vs host disease), healthy tissues from the human donor are xenografted onto a healthy immunocompetent mouse recipient. To study the preclinical efficacy or safety of a candidate drug in treating a human disease, patient or diseased human tissue is xenografted onto a mouse recipient. In order to sustain the xenografted human tissue, GvHD needs to be avoided as much as possible. For this purpose, immunodeficient mice are required. Such strains include spontaneous mutant strains such as nude, scid, NOD, NOD-scid, and genetically engineered strains including loss of function mutations of Rag1, Rag2, Il2rg, B2m, HLA and their various combinations.
Cell Derived Xenograft (CDX) Models
Cell line-derived xenograft models (CDX models) are in vivo models where human-derived tumor cells are transplanted into the mice for efficacy evaluation or tumor-related research. It is one of the most frequently used in vivo models for preclinical analyses of anticancer medicines.
GemPharmatech has developed a large source of human CDX (cell derived xenograft) tumor models to support our effort in preclinical testing of novel anti-tumor therapeutics. For this purpose, these xenografts are indispensable and complementary components with our novel immunodeficient mouse models. GemPharmatech's extensive selection of CDX cell lines, including pancreatic cancer, breast cancer, colon cancer, lung cancer, and lymphoma, can accommodate the requirements of various pharmacodynamic and efficacy investigations.
Patient Derived Xenograft (PDX) Models
Patient-derived tumor xenograft (PDX) models have attracted increasing attention in recent years as a preclinical animal model for cancer research. By transplanting fresh tumor tissue from patients into immunodeficient mice, PDX models can preserve the heterogeneity and complexity of the original tumors and more accurately reflect the biological characteristics, pathological classification, molecular marker expression, gene mutation types, and other features of patient tumors. Compared with traditional cell line-derived xenograft models, PDX models have shown great potential in drug screening, drug development, and personalized medicine due to their ability to recapitulate the patient's tumor microenvironment and predict treatment response.
Discover a world of possibilities with GemPharmatech's diverse range of PDX models. Our innovative PDX models, developed with cutting-edge technology, offer unparalleled accuracy and are trusted by leading pharmaceutical institutions worldwide.