BKS-Lepr^em2Cd479/Gpt

BKS-db|Strain NO.T002407

Knockout (KO)

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BASIC INFORMATION

Strain Name:	BKS-Lepr^em2Cd479/Gpt
Strain Number:	T002407
Official Symbol:	Lepr,db
Strain Strategy:	T002407.BKS-db strain info.pdf
Official Full Name:	leptin receptor
Also Known As:	LEPROT,Leprb,Modb1,OB-RGRP,Obr,db,diabetes,obese-like,obl
NCBI Number:	16847
MGI Number:	104993
Chromosome:	4
Research Areas:	Disease Models,Metabolic Disease,Diabetes model,Obesity model
Strain Background:	[N000214] C57BLKS/JGpt
Modification Type:	Knockout (KO)
Inventory Status:	Live,Cryopreserved
Sale Status:	IF (Available for Distribution)
Health Status:	Specific pathogen free (SPF)
Health Report:	Please log in to view
Publications:	1. Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice 2. Aqueous extract of Scrophularia ningpoensis improves insulin sensitivity through AMPK-mediated inhibition of the NLRP3 inflammasome 3. Celastrol inhibits TXNIP expression to protect pancreatic β cells in diabetic mice 4. Inulin-Type Fructans Change the Gut Microbiota and Prevent the Development of Diabetic Nephropathy 5. Hepatic leptin signaling improves hyperglycemia by stimulating MAPK phosphatase-3 protein degradation via STAT3 6. A novel mouse model of diabetes, atherosclerosis and fatty liver disease using an AAV8-PCSK9-D377Y injection and dietary manipulation in db/db mice 7. m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin 8. Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation 9. Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus 10. VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy 11. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism 12. Peroxiredomin-4 ameliorates lipotoxicity-induced oxidative stress and apoptosis in diabetic cardiomyopathy 13. MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice 14. Human foreskin-derived dermal stem/progenitor cell-conditioned medium combined with hyaluronic acid promotes extracellular matrix regeneration in diabetic wounds 15. High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy 16. Cdk5-mediated phosphorylation of Sirt1 contributes to podocyte mitochondrial dysfunction in diabetic nephropathy 17. Hydralazine as a Versatile and Universal Matrix for High-Molecular Coverage and Dual-Polarity Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging 18. circRNA_010383 acts as a sponge for miR-135a, and its downregulated expression contributes to renal fibrosis in diabetic nephropathy 19. A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis 20. CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis 21. RIPK3-Mediated Necroptosis in Diabetic Cardiomyopathy Requires CaMKII Activation 22. Purβ promotes hepatic glucose production by increasing Adcy6 transcription 23. Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo 24. SIK2 protects against renal tubular injury and the progression of diabetic kidney disease 25. A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice 26. Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation 27. Pancreatic alpha cell glucagon-liver FGF21 axis regulates beta cell regeneration in a mouse model of type 2 diabetes 28. ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation 29. Positive feedback loop of miR-320 and CD36 regulates the hyperglycemic memory-induced diabetic diastolic cardiac dysfunction 30. THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic beta-cell function and preserving beta-cell mass 31. Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing 32. A novel mouse model of heart failure with preserved ejection fraction after chronic kidney disease induced by retinol through JAK/STAT pathway 33. Balancing adipocyte production and lipid metabolism to treat obesity-induced diabetes with a novel proteoglycan from Ganoderma lucidum 34. Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro 35. mPGES-2 blockade antagonizes β-cell senescence to ameliorate diabetes by acting on NR4A1 36. Identification and validation of voltage-dependent anion channel 1-related genes and immune cell infiltration in diabetic nephropathy 37. Sodium tanshinone IIA sulfonate ameliorates neointima by protecting endothelial progenitor cells in diabetic mice 38. Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice 39. Diabetes mellitus promotes the nasal colonization of high virulent Staphylococcus aureus through the regulation of SaeRS two-component systemnasal colonized S. aureus in type 2 diabetes 40. Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice 41. Lentinan alleviates diabetic cardiomyopathy by suppressing CAV1/SDHA-regulated mitochondrial dysfunction 42. Trigonelline inhibits tubular epithelial-mesenchymal transformation in diabetic kidney disease via targeting Smad7 43. Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease 44. Excessive iron inhibits insulin secretion via perturbing transcriptional regulation of SYT7 by OGG1 45. ApoSEVs-Mediated Modulation of Versatile Target Cells Promotes Diabetic Wound Healing: Unveiling a Promising Strategy 46. Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis 47. Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus 48. Ketohexokinase-dependent metabolism of cerebral endogenous fructose in microglia drives diabetes-associated cognitive dysfunction 49. Nephropathy Is Aggravated by Fatty Acids in Diabetic Kidney Disease through Tubular Epithelial Cell Necroptosis and Is Alleviated by an RIPK-1 Inhibitor 50. Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy 51. Depletion of gut microbiota facilitates fibroblast growth factor 21-mediated protection against acute pancreatitis in diabetic mice 52. Fatty acid beta-oxidation and mitochondrial fusion are involved in cardiac microvascular endothelial cell protection induced by glucagon receptor antagonism in diabetic mice 53. Pancreatic Cancer: An Exocrine Tumor with Endocrine Characteristics 54. Sodium butyrate improves mitochondrial function and kidney tissue injury in diabetic kidney disease via the AMPK/PGC-1alpha pathway 55. Targeting YAP1-regulated Glycolysis in Fibroblast-Like Synoviocytes Impairs Macrophage Infiltration to Ameliorate Diabetic Osteoarthritis Progression 56. MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease 57. The Synergism of Human Lactobacillaceae and Inulin Decrease Hyperglycemia via Regulating the Composition of Gut Microbiota and Metabolic Profiles in db/db Mice 58. Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding 59. Early detection of cardiac fibrosis in diabetic mice by targeting myocardiopathy and matrix metalloproteinase 2 60. Ultrasound Deep Brain Stimulation Regulates Food Intake and Body Weight in Mice 61. Dock5 Deficiency Promotes Proteinuric Kidney Diseases via Modulating Podocyte Lipid Metabolism 62. Diabetes mellitus promotes the nasal colonization of high virulent Staphylococcus aureus through the regulation of SaeRS two-component system 63. (Pro)renin receptor mediates tubular epithelial cell pyroptosis in diabetic kidney disease via DPP4-JNK pathway 64. Aged oolong tea manages type 2 diabetes mellitus by inhibiting fat ectopic deposition and alleviating insulin resistance in db/db mice 65. Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)66. Network Pharmacology, Molecular Docking, and Experimental Verification to Reveal the Mitophagy-Associated Mechanism of Tangshen Formula in the Treatment of Diabetic Nephropathy 67. The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice 68. Jiao-tai-wan and its effective component-berberine improve diabetes and depressive disorder through the cAMP/PKA/CREB signaling pathway 69. Leptin receptor deficiency impedes metabolic surgery related-weight loss through inhibition of energy expenditure in db/db mice 70. Compound Danshen dripping pills prevent early diabetic retinopathy: roles of vascular protection and neuroprotection 71. Trimethylamine N-oxide impairs beta-cell function and glucose tolerance 72. VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy 73. MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus 74. Assessment of Reference Genes Stability in Cortical Bone of Obese and Diabetic Mice 75. PPARalpha/delta dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells 76. Label-free analysis of the beta-hydroxybutyricacid drug on mitochondrial redox states repairment in type 2 diabetic mice by resonance raman scattering 77. Knockdown of ACOT4 alleviates gluconeogenesis and lipid accumulation in hepatocytes 78. Noninvasive Monitoring of Early Cardiac Fibrosis in Diabetic Mice by [(68)Ga]Ga-DOTA-FAPI-04 PET/CT Imaging 79. Replenishment of mitochondrial Na(+) and H(+) by ionophores potentiates cutaneous wound healing in diabetes 80. Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate 81. Augmenter of liver regeneration knockout aggravates tubular ferroptosis and macrophage activation by regulating carnitine palmitoyltransferase-1A-induced lipid metabolism in diabetic nephropathy 82. CHILKBP protects against podocyte injury by preserving ZO-1 expression 83. Mitochondrial glycerol 3-phosphate dehydrogenase deficiency exacerbates lipotoxic cardiomyopathy 84. Pinctada martensii Hydrolysate Modulates the Brain Neuropeptidome and Proteome in Diabetic (db/db) Mice via the Gut–Brain Axis 85. Netrin-1 co-cross-linked hydrogel accelerates diabetic wound healing in situ by modulating macrophage heterogeneity and promoting angiogenesis 86. The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair 87. Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption 88. Inhibition of endoplasmic reticulum stress and excessive autophagy by Jiedu Tongluo Tiaogan Formula via a CaMKKbeta/AMPK pathway contributes to protect pancreatic beta-cells 89. Lactate drives epithelial-mesenchymal transition in diabetic kidney disease via the H3K14la/KLF5 pathway 90. Plasma Asprosin Concentrations are Associated with Progression of Diabetic Kidney Disease 91. Supplementation of Clostridium butyricum Alleviates Vascular Inflammation in Diabetic Mice 92. A neural-mast cell axis regulates skin microcirculation in diabetes 93. Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage 94. Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway 95. Sodium Tanshinone IIA Sulfonate alleviates vascular senescence in diabetic mice by modulating the A20-NFkappaB-NLRP3 inflammasome-catalase pathway 96. Autophagy-enabled protein degradation: Key to platelet activation and ANGII production in patients with type 2 diabetes mellitus 97. A High-Carbohydrate Diet Induces Cognitive Impairment and Promotes Amyloid Burden and Tau Phosphorylation via PI3K/Akt/GSK-3beta Pathway in db/db Mice 98. Human adipose‐derived multipotent stromal cells enriched with IL‐10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift 99. RTP4 Enhances Corneal HSV-1 Infection in Mice With Type 2 Diabetes Mellitus 100. Reshaped commensal wound microbiome via topical application of Calvatia gigantea extract contributes to faster diabetic wound healing 101. SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization 102. Unlocking the role of wound microbiome in diabetic, burn, and germ-free wound repair treated by natural and synthetic scaffolds 103. DeSUMOylation of RBMX regulates exosomal sorting of cargo to promote renal tubulointerstitial fibrosis in diabetic kidney disease 104. Increase of PCSK9 expression in diabetes promotes VEGFR2 ubiquitination to inhibit endothelial function and skin wound healing 105. Improvement of MASLD and MASH by suppression of hepatic N-acetyltransferase 10 106. Single‐Cell RNA Sequencing Uncovers Pathological Processes and Crucial Targets for Vascular Endothelial Injury in Diabetic Hearts 107. Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expression 108. Eldecalcitol ameliorates diabetic osteoporosis and glucolipid metabolic disorder by promoting Treg cell differentiation through SOCE 109. Fam3a-mediated prohormone convertase switch in α-cells regulates pancreatic GLP-1 production in an Nr4a2-Foxa2-dependent manner 110. SREBP1 induction mediates long-term statins therapy related myocardial lipid peroxidation and lipid deposition in TIIDM mice 111. Programmed BRD9 Degradation and Hedgehog Signaling Activation via Silk‐Based Core‐Shell Microneedles Promote Diabetic Wound Healing 112. Wogonin mitigates microglia-mediated synaptic over-pruning and cognitive impairment following epilepsy 113. The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity 114. Mouse Bladder Smooth Muscle Lack the Functional Active NMDAR 115. Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC‐1α‐mediated Transcriptional Coactivation 116. GSDMD Mediates Ang II-Induced Hypertensive Nephropathy by Regulating the GATA2/AQP4 Signaling Pathway 117. DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1 118. Dihydro‐resveratrol ameliorates NLRP3 inflammasome‐mediated neuroinflammation via Bnip3‐dependent mitophagy in Alzheimer's disease 119. TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla 120. Defining the features and structure of neutralizing antibody targeting the silent face of the SARS‐CoV‐2 spike N‐terminal domain 121. Nuclear Factor Erythroid 2-Related Factor 2 Activator DDO-1039 Ameliorates Podocyte Injury in Diabetic Kidney Disease via Suppressing Oxidative Stress, Inflammation, and Ferroptosis 122. Lactobacillus reuteri-Enriched Eicosatrienoic Acid Regulates Glucose Homeostasis by Promoting GLP-1 Secretion to Protect Intestinal Barrier Integrity 123. Berberine alleviates AGEs-induced ferroptosis by activating NRF2 in the skin of diabetic mice 124. Jinlida granules alleviate podocyte apoptosis and mitochondrial dysfunction via the AMPK/PGC-1α pathway in diabetic nephropathy 125. "YTHDF3 suppresses declines in corneal epithelial wound healing through upregulating the Wnt/β-catenin signaling pathway and THBS2 expression in diabetic corneas"126. Mass Spectrometry Imaging Reveals Spatial Metabolic Alterations and Salidroside's Effects in Diabetic Encephalopathy
Gene Family:	CD molecules Immunoglobulin like domain containing