Anti-CD40 Induced Colitis Models

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Model strategy


  • Experimental mouse strains: RAG-/-, 6-7weeks old, female

  • Modeling reagents: anti-CD40 antibody

  • Modeling method:


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Short modeling time (7 days), ease of use (upon injection of anti-CD40 antibody);

Evaluate the innate immune response in disease using cytokine profiling of : IFN-γ、IL-12、IL-23、TNF-α.


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Spleen and mesenteric lymph node(mLN) weight increase was observed in anti-CD40 induced model.


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Spleen, mesenteric lymph node (mLN) and colon weight increase was observed in anti-CD40 induced model. 


ELISA 


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Cytometric bead array 


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Serum IL-12, IL-23, IL-6,TFN-α and IFN-γ levels were elevated in anti-CD40-induced model.


Cytometric bead array 


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Colon IL-6,TFN-α and IFN-γ cytokines protein level was significantly increased in anti-CD40-induced model.


RT-QPCR


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Colon IL-12, IL-6,TFN-α, IL17A and IFN-γ cytokines mRNA level was significantly increased in anti-CD40 induced model.


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H&E staining of colon demonstrating histopathological features associated with anti-CD40 induced colitis 

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