Myasthenia Gravis

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Neuroimmune Diseases Models and Efficacy Services
Multiple Sclerosis (MS) ModelsMyasthenia Gravis (MG) Models
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Immune Reconstitution Autoimmune Disease Models and Efficacy Services
SLEIBDArthritisMyasthenia GravisPassive Cutaneous AnaphylaxisPassive Systemic Anaphylaxis (PSA)

Myasthenia gravis (MG) is an autoimmune disease characterized by ptosis, fatigue, and muscle weakness, caused by the association of pathogenic autoantibodies with postsynaptic membrane proteins at neuromuscular junctions. Eighty percent to 90% of cases are mediated by antibodies directed against the acetylcholine receptor (AChR).

 

Strategy of  patient derived PBL-NCG MG Model


Peripheral blood lymphocytes (PBLs) derived from MG patients were infused into NCG (strain No.T001475) mice to generate a MG disease model.


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Igs levels in serum

 

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The level of anti-human AChR antibody and human IgG in the serum increased in model group G2.

 

Limb grip test and pathohistological study

 


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A decrease in limb grip was observed with a corresponding increase in the HE score of Tibialis anterior and gastrocnemius muscle within the model group.

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