CDX Cell Lines

Cell line-derived xenograft models (CDX models) are in vivo models where human-derived tumor cells are transplanted into the subcutis of mice for efficacy evaluation or tumor-related research; It is one of the most frequently used in vivo models for preclinical analyses of anticancer medicines.

GemPharmatech's extensive selection of CDX cell lines, including pancreatic cancer, breast cancer, colon cancer, lung cancer, and lymphoma, can accommodate the requirements of various pharmacodynamic and efficacy investigations. On top of this wide selection, GemPharmatech has engineered 32 CDX cell lines with luciferase to enable non-invasive tumor volume analysis using bioluminescence. 

Cancer TypeUnmodified Cell LineLuciferase-Tagged Cell Line
AdemocarcimomaCalu-3, NCI-H1666, NCI-H441,NCI-H1650
Acute Myeloid LeukemiaMOLM13, OCIAML3
Anaplastic CarcinomaCalu-6
Barett AdenocarcinomaOE33
Bladder CancerUM-UC-3, HT1376, RT4, T24, RT112/84
Brain CancerU251, U-87 MG
Breast CancerBT-20, BT-474, BT-549, HCC1937, HCC1954, HCC1569, Hs 578T, JIMT-1, MCF7, MDA-MB-175VII, MDA-MB-231, MDA-MB-436, MDA-MB-453, MDA-MB-468, SK-BR-3, HCC70, T47DMDA-MB-468-Luc, MDA-MB-231-Luc, MCF-Luc
Clear Cell CarcinomaEs-2
Colorectal CancerColo205, HCT-116, HT29, HT-55,  LoVo, LS174T, RKO, SW48
Colorectal Cancer; Dukes' Type CLs1034
Colorectal Cancer; Dukes' Type C, Grade IIISW948
Colorectal Cancer; Dukes' Type BSW480
Colon Cancer
HT-29-Luc, HCT116-Luc, RKO-Luc
Colon AdenocarcinomaCOLO-320
Duodenal CancerHuTu 80
Endometrial CarcinomaHEC-1-A
Gastric CancerHs 746T, MKN45, NCI-N87, SGC-7901, SNU-16, KATOIII, NUGC4
U251-Luc, U87 MG-Luc
LeukemiaHL-60, Jurkat, K562, MOLT-4, MV-4-11, Nalm-6, SUP-B15, THP-1, CCRF-CEM, Hut78, TF1, Hs 505.TNalm6-Luc, K562-Luc, MOLM 13-Luc, HL60-Luc, MV-4-11-Luc, Jurkat-Luc
Liver CancerHepG2, Huh7Huh7-Luc, HepG2-Luc
Lung Cancer
A549-Luc, NCI-H82, NCI-H2171
LymphomaU937, NK92, Jeko-1, Daudi, Ramos, JVM-2, KAPPAS 299, Raj, SU-DHL-10, SU-DHL-16, U-2932, L-540Raji-Luc, U-937-Luc, MM.1S-Luc, Jeko-Luc, Thp-1-Luc, Daudi-Luc, Ramos
MelanomaA375, COLO829, SK-MEL-28, SK-MEL-5A375-Luc
Multiple MyelomaNCI-H929, MM.1R, MOLP-8, RPMI-8226,  MM.1SRPMI8226-Luc
NeuroblastomaIMR-32, SK-N-BE(2)
NSCLCA549, HCC-827, NCI-H1703, NCI-H1755, NCI-H1975, NCI-H2122, NCI-H358, NCI-H460, NCI-H1299, NCI-H647
Ovarian CancerOVCAR-3, SK-OV-3, TOV-112DSKOV3-Luc, OVCAR-Luc
Pancreatic CancerAsPC-1, BxPC-3, CAPAN-1, CFPAC-1, HPAC, MIA PaCa-2, PANC-1, SW1990PANC-Luc
Prostate Cancer22RV1, LNCaP, PC-3, LNCaP C4-2B
Pulmonary Mucoepidermoid CarcinomaNCI-H226, NCI-H292, NCI-H727, NCI-H69
Renal CarcinomaACHN, 786-O
SarcomaHT1080, SJSA-1, U-2 OS
SCLCDMS-53, NCI-2171, NCI-H446, NCI-H526, NCI-H82, SHP-77
Skin CancerA431
Submandibular Adenosquamous CarcinomaA253
Squamous Cell CarcinomaFaDu
Tongue Squamous Cell CarcinomaCal 27
Uterine Cancer


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