Cell Line Customization Services

Custom Model Generation Services
Preclinical Testing Services
Bioanalytical ServicesPhenotyping ServicesAnti-Tumor Drug Efficacy EvaluationNon-GLP Toxicity Assessment ServicesMetabolic Disease Efficacy EvaluationAutoimmune Disease Efficacy EvaluationNeurodegenerative Disease Efficacy EvaluationCell Therapy & Gene Therapy Efficacy Evaluation
Germ-Free and Microbiome Services
Mouse-Derived Gut Microbiota LibraryCustomized Germ-free ServicesEvaluation of Anti-tumor Effect of Gut MicrobiotaMicrobiota Extraction and TransplantationGerm-free Rederivation and BreedingMicrobial Strain Culture and Colonization
Cell Lines and Customization Services
Cell Line Customization ServicesSyngeneic Cell LinesReporter Cell LinesCDX Cell Lines
Custom Breeding Services
Customized Mice Breeding ServicesCryopreservation and ResuscitationAssisted ReproductionMouse Rederivation Service
Animal Quality Testing Services
SNP Testing ServicesMicrobiology Testing ServicesGenetic IntegrityAnimal HealthAnimal Welfare
Assay Capabilities
Molecular PlatformPK/PD PlatformPathological Diagnosis PlatformCell-based Service PlatformFlow Cytometry PlatformImaging and Analysis PlatformBehavioral Analysis Platform
NeoMab Fully-Human Antibody Discovery Service
Other Services
Animal Facility and HusbandryReproductive and Embryology Services Isolation of Embryonic Fibroblasts

GemPharmatech has applied its years of gene editing experience and expertise from generating genetically engineered mouse models to engineering mouse and human cell lines, in particular syngeneic and patient-derived human tumor cells.

Building on top of an extensive collection of 27 syngeneic cell lines, several of the most popular colorectal, breast, melanoma and liver cancer cell lines have been engineered to express human target genes, including popular IO targets such as PDL1, CD47, CD73, CD39, Nectin4, B7H3, ROR1, CD24A, CD39 and more, providing a growing resource for immune checkpoint drug efficacy evaluation as the filed grows and evolves. 21 of such humanized murine cell lines are available for efficacy services provided by GemPharmatech. 

To enable in-vivo non-invasive imaging of tumor growth, GemPharmatech has generated 30 luciferase-tagged murine and human cell lines, comprising solid and hematological malignancies. This provides a valuable tool set for evaluating efficacy of new therapies, treating not only solid tumors, but also liquid and metastatic tumors. These cell lines are also available for efficacy services provided by GemPharmatech.

With these successful applications of engineered cell lines in preclinical studies, GemPharmatech offers cell line engineering services to its clients. Ship your wildtype cell lines and we will return custom-engineered cell lines to you. 


TypesTimes
Humanized mouse tumor cell line customization (One target)+ In-vivo mouse tumorigenicity test3-4 months+ 2 months
Humanized mouse tumor cell line customization (Multiple targets)+ In-vivo mouse tumorigenicity testInquire+ 2 months
Gene knockout cell line customization+ In-vivo mouse tumorigenicity test2-3 months+ 2 months
Transgene overexpression cell line customization (Including reporter genes such as Luciferase) + In-vivo mouse tumorigenicity test2-3 months+ 2 months


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