CCl4-induced Liver Fibrosis Models

Obesity Models and Efficacy Services
60% HFD Induced Obesity (DIO) models45% HFHSD Induced Obesity(DIO) modelsC57BL/6-Alms1-delWild Mouse 750
Type II Diabetes Models and Efficacy Service
BKS-dbHFHSD+STZ Induced Diabetes Models
Liver Disease Models and Efficacy Services
CCl4-induced Liver Fibrosis ModelsHFD+CCl4-induced MASH ModelsBKS-db MASH ModelsB6-Alms1-del MASH ModelsOther MASH Models
Atherosclerosis Models and Efficacy Services
ApoE KO ModelsLdlr KO Models
Hyperlipidemia Models and Efficacy Services
hPCSK9-UTR ModelshPCSK9 Models
Gout/Hyperuricemia Models and Efficacy Services
Monosodium Urate (MSU)-induced Gouty Arthritis ModelsUrate Oxidase Knockout (Uox-KO) Gout Models

Strain: C57BL/6 mouse and other strains

Experimental Period: 8-10 weeks

Number of lab animals: 10 per group, 6-8 groups


Data Validation

1. Sirius Red staining of liver slices in CCl4-injected mice

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Figure 1. 6-week-old C57BL/6J mice were subcutaneously injected 5 mL/kg of 20% CCl4 (twice weekly) for 10 weeks, whereas control mice were given the same volume of olive oil. Liver slices stained with Sirius Red revealed significant fibrosis in the CCl4-injected group.


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