BKS-db

Research Overview

Figure 1. Overview of the BKS-db model study. 8–12 weeks is experimental period, the mice were randomly divided into 5-8 groups (10-12 mice per group).  

Data Validation

1. Body Weight Curve

Figure 2. The body weight of BKS-db mice increased rapidly after 4-weeks-old. Data are presented as Mean ± SEM, n=20.

2. Blood Glucose Levels

Figure 3. Blood glucose of BKS-db mice increased significantly compared with the control group, and remained stable after 8-week-old. Data are presented as Mean ± SEM, n=6.

3. Insulin levels

Figure 4. The insulin level in BKS-db was higher than the control in 8-week-old. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SEM, n=6 for each group. ****, P<0.0001.

4. Blood Lipid levels

Figure 5. The Chol, TG, HDL-C and LDL-C levels in BKS-db mice were higher than control after 8 weeks. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SEM, n=20. ****, P<0.0001.

5. Liver Function

Figure 6. The serum ALT and AST in BKS-db mice were significantly higher than that in BKS mice for the 8-week-old. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SEM. *, P<0.05; ****, P<0.0001.

6. Fatty Liver and Pancreatic Islet Cell Lesions

Figure 7. BKS-db mice showed significant hepatic steatosis and islet architecture changes in the pancreas after 12 weeks old.

7. Early Stage of Diabetic Kidney Disease

Figure 8. The urinary mAlb level was significantly increased in BKS-db mice from 12 weeks old. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SD. *, P<0.05.

Efficacy Data

1. Effects of Drug on Blood Glucose in BKS-db Mice

Figure 9. Test drug treatment significantly reduced the blood glucose in BKS-db mice. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SEM. **, P<0.01; ***, P<0.00 .