Monosodium Urate (MSU)-induced Gouty Arthritis Models

Obesity Models and Efficacy Services
60% HFD Induced Obesity (DIO) models45% HFHSD Induced Obesity(DIO) modelsC57BL/6-Alms1-delWild Mouse 750
Type II Diabetes Models and Efficacy Service
BKS-dbHFHSD+STZ Induced Diabetes Models
Liver Disease Models and Efficacy Services
CCl4-induced Liver Fibrosis ModelsHFD+CCl4-induced MASH ModelsBKS-db MASH ModelsB6-Alms1-del MASH ModelsOther MASH Models
Atherosclerosis Models and Efficacy Services
ApoE KO ModelsLdlr KO Models
Hyperlipidemia Models and Efficacy Services
hPCSK9-UTR ModelshPCSK9 Models
Gout/Hyperuricemia Models and Efficacy Services
Monosodium Urate (MSU)-induced Gouty Arthritis ModelsUrate Oxidase Knockout (Uox-KO) Gout Models

Injecting urate into local tissues or joints of C57BL/6JGpt mice causes the accumulation of urate crystals, which can effectively replicate acute gout-like symptoms in humans. These mice can be utilized as a suitable model for preclinical research of gout and anti-inflammatory medications.


Validation Data

1.Paw Swelling

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Figure 1. Monosodium urate (MSU) was injected subcutaneously into the hind paw. Mouse paw thickness was monitored at multiple time points by a automatic gauge. The paw swelling was visible after MSU injection and reached the peak value at 8 hours. Data were presented as Mean±SD.


2.Paw Morphology

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Figure 2. The shape of the right hind paw of the same mouse before MSU injection (left) and 24 hours after MSU injection (right). Significant swelling of the paw was observed after MSU injection, compared to the control group.


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