HFHSD+STZ Induced Diabetes Models

Obesity Models and Efficacy Services
60% HFD Induced Obesity (DIO) models45% HFHSD Induced Obesity(DIO) modelsC57BL/6-Alms1-delWild Mouse 750
Type II Diabetes Models and Efficacy Service
BKS-dbHFHSD+STZ Induced Diabetes Models
Liver Disease Models and Efficacy Services
CCl4-induced Liver Fibrosis ModelsHFD+CCl4-induced MASH ModelsBKS-db MASH ModelsB6-Alms1-del MASH ModelsOther MASH Models
Atherosclerosis Models and Efficacy Services
ApoE KO ModelsLdlr KO Models
Hyperlipidemia Models and Efficacy Services
hPCSK9-UTR ModelshPCSK9 Models
Gout/Hyperuricemia Models and Efficacy Services
Monosodium Urate (MSU)-induced Gouty Arthritis ModelsUrate Oxidase Knockout (Uox-KO) Gout Models

Research Overview

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Figure 1. Overview of (high-fat-high-sugar diet) HFHSD combined with streptozotocin (STZ) to induce type II diabetes model. 8-12 weeks marked the experimental period, where mice were randomly divided into 5-8 groups (10-12 mice per group).


Data Validation

1. Body Weight Curve

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Figure 2. Obesity phenotype was not observed in model group after STZ injection. Data are presented as Mean±SEM. n=5-50.


Efficacy Data

1. Blood Glucose Levels and HbA1c

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Figure 3. Test drug significantly reduced the fasting blood glucose and HbA1c levels. Statistical analysis by two-tailed unpaired t test, data are presented as Mean±SEM, n=5-10. ****, P<0.0001.


2. Glucose Tolerance Test

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Figure 4. Test drug significantly improved the glucose intolerance of diabetic mice. Statistical analysis by one way ANOVA with Tukey’s post hoc test, data are presented as Mean±SEM. n=5-10. ****, P<0.0001.


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