Ldlr KO Models

The Low-Density Lipoprotein Receptor (LDLR) is a member of the lipoprotein receptor family that clears low-density lipoprotein (LDL) and intermediate-density lipoprotein (IDL) to regulate plasma cholesterol levels. GemPharmatech generated an LDLR knockout mouse on the C57BL/6 background by using CRISPR/Cas9 technology. In LDLR knockout mice, the introduction of a western diet can promote the incidence and development of atherosclerosis.


Strain: B6/JGpt-Ldlrem1Cd82/Gpt

Number of lab animals: 5-10 per group, 3-8 groups


Data Validation:

  1.  Plasma Chol and LDL-C


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    Figure 1. Under normal or western diet conditions, plasma cholesterol and LDL levels were shown to be increased in ldlr-/- mice. Data are presented as Mean±SEM.

                                                  


2. Pathology

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Figure 2. Elevated levels of plasma cholesterol and LDL were observed in ApoE-/- mice either under normal and western diet.


Efficacy Data:

 

1. Plasma Chol, LDL-C and TG

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Figure 3. MGL-3196 reduced total cholesterol, LDL, and triglyceride levels in the Ldlr KO model. The data are presented as Mean±SD, n=6. *,P<0.05 by unpaired two-tailed student's t-test.


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