Atherosclerosis Models and Efficacy Services
Atherosclerosis is a chronic disease caused by the deposition of fat, cholesterol, calcium, and other chemicals in the endothelium of arteries, resulting in the loss of arterial elasticity due to vessel thickening and sclerosis. Once thick plaque substantially blocks the arteries, it can significantly limit blood flow to the vessels serving the tissues, resulting in severe tissue damage. GemPharmatech has developed ApoE knockout models and Ldlr knockout models that can be used to study atherosclerosis and efficacy evaluation services for the related drugs.
- Atherosclerosis Models
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- ApoE KO model: ApoE KO mice were constructed by knocking out ApoE in C57BL/6JGpt mice using CRISPR/Cas9 technology and induced by a Western diet to promote the development and progression of atherosclerosis.
- Ldlr KO model: Ldlr KO mice were constructed by knocking out Ldlr C57BL/6JGpt using CRISPR/Cas9 technology and induced by a Western diet promoted the development and progression of atherosclerosis.
- Atherosclerosis-related target humanized mouse models.
- Test items
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- Body weight, blood lipids, pathological tests (immunohistochemistry, special staining, etc.),
- Protein immunization, qRT-PCR, etc.