Gout/Hyperuricemia Models and Efficacy Services

Hyperuricemia is a common purine metabolic disorder caused by excessive synthesis or decreased excretion of uric acid as a result of abnormalities in the purine metabolic pathway. A significant risk factor for the development of gout, Hyperuricemia also increases the risk of cardiovascular disease and chronic renal failure. GemPharmatech has developed gout and hyperuricemia models via gene editing and drug induction, and can also provide model-based therapeutic efficacy evaluation services. By injecting uric acid into the local tissues or joints of mice, we have additionally successfully reproduced the symptoms of acute gout in humans.

-Uox KO gout mouse model
-MSU-induced gouty arthritis mouse model

Test Items

-Observation of the degree of mice paw swelling
-Detection of inflammatory factors in blood (ELISA Kit), histopathological analysis (H&E staining, etc.), gene expression analysis (qRT-PCR & WB).

Monosodium Urate (MSU)-induced Gouty Arthritis ModelsUrate Oxidase Knockout (Uox-KO) Gout Models

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