Type II Diabetes Models and Efficacy Services

Diabetes mellitus is a common disease caused by genetic, environmental, and immunological factors resulting in islet hypofunction and insulin resistance, and revealing complex metabolic disorders involving sugar, protein, fat, water, and electrolytes. More than 90% of patients with diabetes have type II diabetes(T2D). GemPharmatech has generated the matching diabetes mellitus models using gene-editing technology and a diet-induced modeling approach for researching type II diabetes mellitus pathogenesis as well as evaluating therapeutic medication screening.

Type II Diabetes Models

- Single gene mutant mouse model BKS-db: Four-week-old leptin receptor (Ldlr)-deficient BKS-db mice display indications of type II diabetes, including hyperglycemia and hyperinsulinemia.
- HFHSD+STZ induction model: Combining a high-fat-high-sugar diet with a low-dose injection of streptozotocin (STZ) induces T2D symptoms in C57BL/6J mice, which can be used to evaluate the efficacy of anti-T2D medicines.
- Humanized mouse model of type II diabetes-related targets.

Test items

- Body weight, food intake；
- Blood glucose, glycated hemoglobin (HbA1c), GTT/ ITT, serum insulin；
- Body fat percentage, physiological cage test (urine and feces collection), metabolism cage test, blood lipid, evaluation of cytokines and chemokines, etc.

BKS-dbHFHSD+STZ Induced Diabetes Models

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