Psoriasis Models

Wild Mouse 750
Wild Mouse 750
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Wild Mouse 765
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Psoriasis is an immune-mediated inflammatory skin disease, and its pathogenesis is related to inflammatory cell infiltration and inflammatory factors. GemPharmatech has independently developed two disease models: the IMQ-induced psoriasis mouse model and the B6-K14-hIL17A spontaneous psoriasis mouse model.


1. IMQ-induced psoriasis mouse model

Use C57BL/6JGpt and BALB/cJGpt female mice aged 6-8 weeks for the modeling. The modeling method involves continuous topical application of Imiquimod (IMQ) for 7 days.

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Validation data

  • Efficacy results of Dexamethasone and Bifidobacterium in IMQ-induced psoriasis mouse model

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A: Compared with G2 control group, the PASI score of G3 (Dexamethasone) and G4 (Bifidobacterium) groups was significantly decreased, and the silver disease phenotype was significantly alleviated.


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B: Pathologic analysis of back skin.

  

2. B6-K14-hIL17A spontaneous psoriasis mouse model

H11-hKRT14-iCre (T004833) hybridized with Rosa26-CAG-LSL-hIL17A-IRES-EGFP-PolyA (T037029) to drive conditioned overexpression of IL-17A in keratinocytes, resulting in spontaneous psoriasis phenotype in mice.


Validation data

  • Phenotypic data of B6-K14-hIL17A spontaneous psoriasis mouse model

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B6-K14-hIL17A psoriasis mouse model showed a significant psoriasis phenotype. Pathological analysis showed epidermal thickening, absence of granular layer, dermal elongation, hyperkeratosis and dyskeratosis, and multiple neutrophil abscesses in the stratum corneum.