Cytokine Neutralization Assay

Cell Line Engineering
In vitro Pharmacological Evaluation
Antibody Fab Fragment Combination ExperimentADCC Effect Evaluation ExperimentCDC Effect Evaluation ExperimentADCP Effect Evaluation ExperimentImmune Cell Stimulation and Cytokine Release AssayBispecific Antibody T Cell or NK Cell Engager AssayCytokine Neutralization AssayTarget Binding ExperimentsAntibody Internalization AssaysCell Cycle ExperimentsCell Apoptosis ExperimentKilling / Inhibition AssayIn vitro Bystander Effect ExperimentCell Therapy and Gene Therapy
Tumor-bearing Mouse Models

Cytokines are a group of small protein molecules with diverse biological activities. They are synthesized and secreted by stimulated immune cells, including monocytes, macrophages, T cells, B cells, NK cells, and certain non-immune cells like endothelial cells, epidermal cells, and fibroblasts. Cytokines play a crucial role in regulating cell growth, differentiation, and function by binding to their respective receptors, thereby modulating immune responses. Prolonged and excessive secretion of inflammatory cytokines can contribute to the development of autoimmune diseases and cancers. Neutralization experiments aim to measure the ability of neutralizing antibodies to interfere with the biological activity of specific cytokines or proteins.

 

Case: TNF-α neutralization by Adalimumab promotes L929 cell proliferation.


图片6.png图片7.png


Fig. Adalimumab effectively neutralized the killing effect of TNF-α on L929 cell 


GPT Advantages


  • Extensive library of target cells (300+ cancer cell lines and humanized cell lines) and certified BSL-2 level laboratories.

  • Free provision of comparator antibody therapy for common viral infections.

  • Multiple measurement items, including target cell proliferation, apoptosis, and cytokine release.

  • High repeatability and a stable experimental system.

  • Vast project experience.

  • Compliance with regulatory requirements for new drug application submissions.

  • Stringent laboratory data storage standards to ensure experiment traceability.


TALK WITH OUR EXPERTS

GemPharmatech is committed to protecting and respecting your privacy, and we'll only use your personal information to administer your account and to provide the products and services you requested from us. From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you. If you consent to us contacting you for this purpose, please click below to say how you would like us to contact you:

In order to provide you with the content requested, we need to store and process your personal data. If you consent to us storing your personal data for this purpose, please click the checkbox below.

You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.