Lung cancer PDX

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Angiogenesis is closely associated with tumorigenesis, progression, metastasis, and prognosis of lung cancer. This also include neovascularization with unrestricted proliferation of tumor cells. In addition, anti-angiogenic monotherapy has limited clinical efficacy, and drug resistance is evident. As a result, the "A+A" strategy (the combination of two or more anti-angiogenic medications targeting various angiogenic signaling pathways) is thought to achieve more potent anti-tumor effects. Avastin and Erlotinib, for example, were recently approved for the treatment of NSCLC with EGFR-activating mutations, and the results were verified by a phase III clinical trial (NEJ026).

At present, GemPharmatech's extensive collection possesses 6 cases of PDX tumor samples of Lung Cancer.


PDX ID 

Histological type  

 Grade 

  Stage  

WES 

RNA-seq

LC00136

Lung Squamous Cell Carcinoma

Low to medium differentiation

N/A

Y

Y

LC00140

Lung Squamous Cell Carcinoma

Moderate-severe differentiation

N/A

Y

Y

LC00143

Lung Adenocarcinoma

N/A

ⅡA (T2b N0 cM0)

Y

Y

LC00167

Lung Squamous Cell Carcinoma

N/A

N/A

N/A

Y

LC00202

Small Cell Lung Cancer

Poorly differentiated

N/A

YY

LC00256

Lung Squamous Cell Carcinoma

Moderately differentiated

ⅠA3(pT1cN0cM0)

YY


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