Detail information of PDX-LC00143
Growth Properties
Fig 1. Growth Properties
Pathology Diagnosis
Tumor size: mass size 4.5 × 4.5 × 2.8cm.
Histological type: Right upper lung invasive adenocarcinoma (micropapillary type 70%, acinoid type 20%, solid type 10%) accompanied by necrosis.
Stage: II A（T2b, N0, cM0）
IHC: Tumor cells expressed Napsin A (+), TTF-1 (+), ALK (-).
Gene mutation in WES
Table 1. Gene mutation (Partial)
Gene | Hgvs | Priority |
EGFR | p.R521K | L |
KRAS | p.G12C | H |
PD-L1(CD274) | c.*93G>A | L |
ALK | p.I1461V; p.D1529E; p.K1491R | L |
TP53 | p.P33R; p.P72R | L |
ATM | p.G3051V | H L |
RET | p.G691S | L |
PDGFRB | p.I29F | L |
BRCA2 | p.N372H; p.V2466A | L |
CSF1R | p.H362R | L |
FLT3 | p.T227M | L |
TBCE（HRD） | p.R223W | H |
Gene fusion in RNA-seq
Table 2. Gene fusion
PDX ID | Gene 1_ Gene 2 |
LC00143 | NACA_ACTB |