Behavioral Tests of Pain

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Pain behavioral tests in animal research are experimental paradigms designed to assess nociception and pain-related behaviors in animals. These tests are critical for studying the mechanisms of pain, evaluating the efficacy of analgesic drugs, and modeling human pain conditions such as neuropathic pain, inflammatory pain, acute pain, and chronic pain syndromes. Pain behavioral tests measure various aspects of pain perception, including thermal sensitivity, mechanical sensitivity, chemical sensitivity, and spontaneous pain behaviors.

 

GemPharmatech provides behavioral tests such as the Von Frey Test and Hot or Cold Plate Test to detect changes in mouse pain-related behaviors.

 

1. Von Frey Test

This test assesses mechanical allodynia (pain from normally non-painful stimuli) and hyperalgesia (increased sensitivity to pain) by applying calibrated filaments to the paw or other body parts. The withdrawal threshold is measured, providing insights into peripheral and central sensitization mechanisms.


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Von Frey Test

 

2. Hot or Cold Plate Test

  • Hot plate test assesses thermal pain sensitivity by placing an animal on a heated surface and measuring the latency to exhibit pain-related behaviors, such as paw licking, shaking, or jumping.

  • Cold plate test assesses cold sensitivity by placing an animal on a cold surface and measuring pain-related behaviors, such as paw lifting or shaking. It is often used in neuropathic pain models.

 

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Hot or Cold Plate Test


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