New Publicatons on the MAPK Signaling Cascade Using GemPharmatech Mice
The Mitogen-activated protein kinase (MAPK) signaling cascade is a crucial pathway involved in the regulation of a wide array of cellular processes, including cell proliferation, differentiation and stress response. It comprises several branches, such as ERK pathway, JNK pathway and P38 pathway, enabling cells to respond to a diverse range of stimuli and influence the progression of cancer, inflammation, and many other diseases.
Explore how GemPharmatech’s mice were used in recent publications on the MAPK signaling cascade!
EIF3H/HAX1 affects colorectal tumorigenesis via RAF-MEK-ERK signaling cascade |
Mouse strains used in this study: Eif3h-flox|T008924, NCG|T001475 Researchers delved deeper into the study[1] of the eukaryotic translation initiation factor 3, subunit h(EIF3H) in colorectal cancer (CRC). They found that EIF3H is overexpressed in CRC, which stabilizes HAX1(HS1 associated protein X-1) and further enhances the interaction between RAF1, MEK1, and ERK1, propelling tumor growth and metastasis. |
Podocyte OTUD5 emerges as a promising drug target for diabetic kidney disease(DKD) |
Mouse strains used in this study: Otud5-flox|T052115, H11-Nphs1-iCre|T005680 Recent research[2] highlighted the therapeutic potential of the ovarian tumor deubiquitinase 5(OTUD5) in DKD. The podocyte OTUD5 removes K63-linked ubiquitin from TAK1, thereby inactivating TAK1 and its downstream TAK1-MAPK pro-inflammatory signaling, reducing podocyte inflammation and injury in DKD. |
Looking for more strains?
Strain ID | Strain Name | Strain Type |
Mapk1-flox[3] | Conditional knockout | |
Conditional knockout | ||
Knockout | ||
Conditional knockout | ||
Conditional knockout | ||
Conditional knockout |
[1] Jin, Huilin, et al. The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression. Nature Communications 15.1 (2024): 2551.
[2] Zhao, Ying, et al. Podocyte OTUD5 alleviates diabetic kidney disease through deubiquitinating TAK1 and reducing podocyte inflammation and injury. Nature Communications 15.1 (2024): 5441.
[3] Xing, Qi, et al. BCL6 is required for the thymic development of TCRαβ+ CD8αα+ intraepithelial lymphocyte lineage. Science Immunology 9.92 (2024): eadk4348.