Developing new drugs requires a significant investment of time and economic costs. Drug repurposing therefore has significant advantages over developing new drugs. Humanized SLE models exhibit similar pathological features to those seen in patients with SLE, such as high levels of auto-antibodies and pathogenic B cells, and respond positively to treatment with potentially repurposed oncology therapeutics. As such, these models are valuable for the evaluation of other future repurposed B cell-directed oncology drugs.​