C57BL/6JGpt-Gsdmdem1Cflox/Gpt
Mouse Model: Gsdmd-flox
Strain Number: T059954
Conditional knockout (cKO)
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- Quantity: - +
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Gsdmdem1Cflox/Gpt |
| Strain Number: | T059954 |
| Official Symbol: | Gsdmd |
| Strain Strategy: | Log in to read more |
| NCBI Number: | 69146 |
| Chromosome: | 15 |
| Distance Between Two Loxps: | 2932bp |
| Research Areas: | mortality/aging,immune system,digestive/alimentary system,hematopoietic system,Cell death,cellular,Cell localization,cell nucleus,cytomembrane,Signal Transduction,Lipid binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | Log in to read more |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Gasdermin D-mediated metabolic crosstalk promotes tissue repair. Nature (2024)2. Rhaponticin Alleviates Collagen-induced Arthritis by Inhibiting NLRP3/GSDMD-mediated Neutrophil Extracellular Traps. Inflammation (2024)3. ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury. Cell death & disease (2025)4. Gasdermin-D-mediated epithelial-immune circuit synchronizes nutrient absorption and host defense in the small intestine. Immunity (2025) |
| Gene Family: | Gasdermins |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.