C57BL/6JGpt-Tg(Thy-APP/Thy-PSEN1)5/Gpt

Mouse Model: FAD4T
Strain Number: T053302

Transgenic (Tg)

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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-Tg(Thy-APP/Thy-PSEN1)5/Gpt
Strain Number: T053302
Official Symbol: APP,PSEN1
Strain Strategy: T053302.FAD4T strain info.pdf
Official Full Name: amyloid beta precursor protein,presenilin 1
Also Known As: AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN-II,PN2,alpha-sAPP,preA4
NCBI Number: 3515663
Research Areas: Disease Models,Neurodegenerative diseases,Alzheimer's disease
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Transgenic (Tg)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. S-nitros(yl)ation of CaMKIIα and its precision redox regulation by SNOTAC plays a critical role in learning and memory. Redox biology (2025)2. IL-17A Induces Circadian Disruptions Through the Epigenetic Repression of BMAL1 in Mice With Alzheimer's Disease. J Cell Mol Med (2025)3. Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating alpha-Secretase. JOURNAL OF NEUROSCIENCE (2024)4. Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer's Disease. Research (2023)5. Mannose-Integrated Nanoparticle Hitchhike Glucose Transporter 1 Recycling to Overcome Various Barriers of Oral Delivery for Alzheimer's Disease Therapy. ACS Nano (2024)6. Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer's disease. Pharmacol Res (2024)7. H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFkappaB signaling pathway. J Neuroinflammation (2023)8. SIRT5-Mediated Desuccinylation of RAB7A Protects Against Cadmium-Induced Alzheimer's Disease-Like Pathology by Restoring Autophagic Flux. Advanced Science (2024)

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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.