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C57BL/6JGpt-Tg(Thy-APP/Thy-PSEN1)5/Gpt

FAD4T|Strain NO.T053302

Transgenic (Tg)

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BASIC INFORMATION
Strain Name: C57BL/6JGpt-Tg(Thy-APP/Thy-PSEN1)5/Gpt
Strain Number: T053302
Official Symbol: APP,PSEN1
Strain Strategy: T053302.FAD 4T strain info.pdf
Official Full Name: amyloid beta precursor protein,presenilin 1
Also Known As: AAA,ABETA,ABPP,AD1,APPI,CTFgamma,CVAP,PN-II,PN2,alpha-sAPP,preA4
NCBI Number: 3515663
Research Areas: Disease Models,Neurodegenerative diseases,Alzheimer's disease
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Transgenic (Tg)
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer's Disease2. H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFkappaB signaling pathway3. Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer's disease4. Mannose-Integrated Nanoparticle Hitchhike Glucose Transporter 1 Recycling to Overcome Various Barriers of Oral Delivery for Alzheimer's Disease Therapy5. Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating alpha-Secretase6. SIRT5-Mediated Desuccinylation of RAB7A Protects Against Cadmium-Induced Alzheimer's Disease-Like Pathology by Restoring Autophagic Flux