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C57BL/6JGpt-H11em1Cin(Syn1-iCre)/Gpt

Model: H11-Syn1-iCre
Strain Number: T052699

Knockin (KI)

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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.

BASIC INFORMATION
Strain Name: C57BL/6JGpt-H11em1Cin(Syn1-iCre)/Gpt
Strain Number: T052699
Official Symbol: Syn1,iCre
Strain Strategy: Log in to read more
Official Full Name: synapsin I
Also Known As: Syn-1,Syn1-S
NCBI Number: 20964
MGI Number: 98460
Chromosome: 11
Research Areas: Tool Mice,Cre/Dre
Strain Background: [N000013] C57BL/6JGpt
Modification Type: Knockin (KI)
Genotyping Protocols: Log in to read more
Inventory Status: Live,Cryopreserved
Sale Status: IF (Available for Distribution)
Health Status: Specific pathogen free (SPF)
Health Report: Please log in to view
Publications: 1. Differential roles of NMDAR subunits 2A and 2B in mediating peripheral and central sensitization contributing to orofacial neuropathic pain. Brain Behav Immun (2022)2. Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice. Sci Signal (2024)3. TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4. International journal of biological sciences (2025)4. Redox regulation of TRIM28 facilitates neuronal ferroptosis by promoting SUMOylation and inhibiting OPTN-selective autophagic degradation of ACSL4. Cell death and differentiation (2025)
Gene Family: Synapsins

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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.

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