C57BL/6JGpt-Cdkn2aem1Cflox/Gpt
Mouse Model: Cdkn2a-flox
Strain Number: T052166
Conditional knockout (cKO)
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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library
With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Cdkn2aem1Cflox/Gpt |
| Strain Number: | T052166 |
| Official Symbol: | Cdkn2a |
| Strain Strategy: | T052166.Cdkn2a Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | cyclin dependent kinase inhibitor 2A |
| Also Known As: | ARF-INK4a,Arf,INK4a-ARF,Ink4a/Arf,MTS1,Pctr1,p16,p16(INK4a),p16INK4a,p19<ARF>,p19ARF |
| NCBI Number: | 12578 |
| MGI Number: | 104738 |
| Chromosome: | 4 |
| Distance Between Two Loxps: | 1844bp |
| Research Areas: | Metabolic research,Developmental Biology,immune system,integument,Tumor research,nervous system,Signal Transduction,skeleton,vision/eye,respiratory system,Cell Proliferation,Cell death,DNA transcription,reproductive system,digestive/alimentary system,Protein metabolism,renal/urinary system,Mitochondrial research,Physiological system,endocrine/exocrine glands,homeostasis/metabolism,behavior/neurological,cell differentiation,Cell biology,Molecular biology,cellular,hematopoietic system,mortality/aging,Cell localization,cell nucleus,DNA binding protein,Regulation of enzyme activity,transferase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T052166.Cdkn2a Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Fibroblasts-specific p16INK4a exacerbates inflammageing-mediated post-infarction ventricular remodelling through interacting with STAT3 to regulate NLRP3 transcription. Clinical and translational medicine (2025) |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.