C57BL/6JGpt-Mlklem1Cflox/Gpt
Mouse Model: Mlkl-flox
Strain Number: T052126
Conditional knockout (cKO)
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Mlklem1Cflox/Gpt |
| Strain Number: | T052126 |
| Official Symbol: | Mlkl |
| Strain Strategy: | T052126.Mlkl Cas9-CKO Strategy-EN.pdf |
| Official Full Name: | mixed lineage kinase domain-like |
| Also Known As: | 9130019I15Rik |
| NCBI Number: | 74568 |
| MGI Number: | 1921818 |
| Chromosome: | 8 |
| Distance Between Two Loxps: | 11976bp |
| Research Areas: | Metabolic research,Protein metabolism,homeostasis/metabolism,immune system,Physiological system,hematopoietic system,Cell biology,Cell death,cellular,Organelles membrane,Molecular biology,Signal Transduction |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | T052126.Mlkl Genotyping Protocol(CKO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Necroptosis-mediated HMGB1 secretion of keratinocytes as a key step for inflammation development in contact hypersensitivity. Cell Death Discov (2022)2. Inflammatory adhesion mediates myocardial segmental necroptosis induced by mixed lineage kinase domain-like protein in acute myocardial infarction. Cell communication and signaling : CCS (2025)3. ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury. Cell death & disease (2025) |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.