C57BL/6JGpt-Tlr4em26Cd1829/Gpt
Mouse Model: Tlr4-KO
Strain Number: T051714
Knockout (KO)
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- Quantity: - +
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GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library
With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Tlr4em26Cd1829/Gpt |
| Strain Number: | T051714 |
| Official Symbol: | Tlr4 |
| Strain Strategy: | T051714.Tlr4 Cas9-KO Strategy-EN.pdf |
| Official Full Name: | toll-like receptor 4 |
| Also Known As: | Lps,Ly87,Ran/M1,Rasl2-8 |
| NCBI Number: | 21898 |
| MGI Number: | 96824 |
| Chromosome: | 4 |
| Deletion (size): | -1829bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Tumor research,nervous system,vision/eye,behavior/neurological,Physiological system,integument,pigmentation,cardiovascular system,skeleton,Muscle ,respiratory system,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,Cell biology,Cell Proliferation,Cell death,cellular,Cell localization,Cytoplasmic vesicle,endosome,Golgi apparatus,Organelles membrane,Molecular biology,Signal Transduction,DNA transcription,hydrolytic enzyme,Lipid binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T051714.Tlr4 Genotyping Protocol(KO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis. Gut (2023)2. Inhibition of Hyperglycemia and Hyperlipidemia by Blocking Toll-like Receptor 4: Comparison of Wild-Type and Toll-like Receptor 4 Gene Knockout Mice on Obesity and Diabetes Modeling. Biology (Basel) (2024)3. Hypercapnia promotes NLRP3 inflammasome activation in microglia by activating P2X7R after lipopolysaccharide-induced activation of the TLR4/NF-κB signaling …. Cytokine (2024)4. Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy. Communications biology (2025)5. Deficiency of Toll-like receptor 4 attenuates airway inflammation and remodeling in an ovalbumine-induced mouse asthma model. J Thorac Dis (2025)6. Streptococcus salivarius-derived ilexgenin A alleviates pneumonia through the gut-lung axis. mSystems (2025) |
| Gene Family: | CD moleculesToll like receptors |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.