C57BL/6JGpt-Gpx4em2Cflox/Gpt
Model: Gpx4-flox
Strain Number: T050827
Conditional knockout (cKO)
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With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Gpx4em2Cflox/Gpt |
| Strain Number: | T050827 |
| Official Symbol: | Gpx4 |
| Strain Strategy: | Log in to read more |
| Official Full Name: | glutathione peroxidase 4 |
| Also Known As: | GPx-4,GSHPx-4,mtPHGPx,snGPx |
| NCBI Number: | 625249 |
| MGI Number: | 104767 |
| Chromosome: | 10 |
| Distance Between Two Loxps: | 11411bp |
| Research Areas: | Metabolic research,homeostasis/metabolism,Developmental Biology,embryo,growth/size/body,mortality/aging,nervous system,behavior/neurological,Physiological system,cardiovascular system,reproductive system,digestive/alimentary system,liver/biliary system,Cell biology,Cell death,Mitochondrial research,cellular,cell nucleus,Organelles membrane,Molecular biology,oxidordeuctase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Conditional knockout (cKO) |
| Genotyping Protocols: | Log in to read more |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. DNA Methylation-Mediated GPX4 Transcriptional Repression and Osteoblast Ferroptosis Promote Titanium Particle-Induced Osteolysis. Research (2024)2. Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis. J Adv Res (2024)3. p23 protects against ferroptosis of brain microvascular endothelial cells in ischemic stroke. International journal of molecular medicine (2025)4. PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid-Induced Osteoporosis by Suppressing Osteocyte Ferroptosis. Adv Sci (Weinh) (2025) |
| Gene Family: | Selenoproteins |
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GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.