C57BL/6JGpt-Sirt3em11Cd1311/Gpt
Mouse Model: Sirt3-KO
Strain Number: T050579
Knockout (KO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
GemPharmatech Offers the World’s Largest Knockout and Conditional Knockout Library
With over 25,000 mouse models available and thousands of new strains developed annually, GemPharmatech has built the world’s largest knockout and conditional knockout resource library. Every model is generated using cutting-edge gene editing and validated at the genomic level to ensure reliability. Choosing GemPharmatech means more than acquiring a mouse model, it means partnering with a global leader committed to scientific rigor, competitive pricing, and timely delivery of the mice models your research requires.
| Strain Name: | C57BL/6JGpt-Sirt3em11Cd1311/Gpt |
| Strain Number: | T050579 |
| Official Symbol: | Sirt3 |
| Strain Strategy: | T050579.Sirt3 Cas9-KO Strategy-EN.pdf |
| Official Full Name: | sirtuin 3 |
| Also Known As: | 2310003L23Rik,AI848213,Sir2l3 |
| NCBI Number: | 64384 |
| MGI Number: | 1927665 |
| Chromosome: | 7 |
| Deletion (size): | -1311bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Lipid Metabolism,Developmental Biology,growth/size/body,immune system,nervous system,behavior/neurological,Physiological system,cardiovascular system,skeleton,digestive/alimentary system,liver/biliary system,Cell biology,Mitochondrial research,cellular,Cell localization,cell nucleus,cytomembrane,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein,hydrolytic enzyme,transferase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T050579.Sirt3 Genotyping Protocol(KO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3-COX4I2 Axis Attenuates Osteoarthritis Progression. Adv Sci (2023)2. SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch. Bone Res (2025) |
| Gene Family: | Sirtuins |
Extend the Value of Your Mouse Models with Integrated Preclinical Services
GemPharmatech not only provides access to advanced genetically engineered mouse models but also offers comprehensive preclinical research services to help you maximize their value. Our scientific team can support your studies from model construction through phenotype validation and pharmacology testing, ensuring that every experiment is designed for translational relevance. By pairing this conditional knockout model with GemPharmatech’s preclinical services, you gain an integrated workflow that accelerates discovery, reduces risk, and produces robust, actionable data.